Issue 3, 2003
From the journal:

Chemical Communications

Binding of an inhibitor of the p53/MDM2 Interaction to MDM2

Sara J. Duncan,a   Matthew A. Coopera  and  Dudley H. Williams*a  

* Corresponding authors

a Dept of Chemistry, Lensfield Rd, Cambridge, UK
E-mail: dhw1@cam.ac.uk
Fax: 44-1223-336913
Tel: 44-1223-336368

Abstract

The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.

Graphical abstract: Binding of an inhibitor of the p53/MDM2 Interaction to MDM2

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Article information

DOI
https://doi.org/10.1039/B211889K
Article type
Communication
Submitted
29 Nov 2002
Accepted
13 Dec 2002
First published
14 Jan 2003

Chem. Commun., 2003, 316-317

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Binding of an inhibitor of the p53/MDM2 Interaction to MDM2

S. J. Duncan, M. A. Cooper and D. H. Williams, Chem. Commun., 2003, 316 DOI: 10.1039/B211889K

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