Issue 3, 2003

Novel intermolecular carbon radical addition to a nitrone: asymmetric synthesis of α-amino acids

Abstract

A nitrone was used as a synthetically useful radical acceptor in carbon–carbon bond-forming radical reactions; the intermolecular addition of alkyl radicals to chiral glyoxylic nitrone was studied; a high degree of stereocontrol in radical addition to glyoxylic nitrone was achieved to provide a new method for asymmetric synthesis of α-amino acids.

Graphical abstract: Novel intermolecular carbon radical addition to a nitrone: asymmetric synthesis of α-amino acids

Supplementary files

Article information

Article type
Communication
Submitted
21 Nov 2002
Accepted
23 Dec 2002
First published
14 Jan 2003

Chem. Commun., 2003, 426-427

Novel intermolecular carbon radical addition to a nitrone: asymmetric synthesis of α-amino acids

M. Ueda, H. Miyabe, M. Teramachi, O. Miyata and T. Naito, Chem. Commun., 2003, 426 DOI: 10.1039/B211570K

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