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Issue 5, 2003
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Asymmetric protonation of lithium enolates of α-amino acid derivatives with α-amino acid-based chiral Brønsted acids

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Abstract

The reaction of lithium enolates of α-amino acid derivatives with chiral amides, easily synthesized from L-tert-leucine, gives corresponding optically active unnatural α-amino acid derivatives with up to 87% ee.

Graphical abstract: Asymmetric protonation of lithium enolates of α-amino acid derivatives with α-amino acid-based chiral Brønsted acids

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Article information


Submitted
18 Nov 2002
Accepted
07 Jan 2003
First published
30 Jan 2003

Chem. Commun., 2003, 566-567
Article type
Communication

Asymmetric protonation of lithium enolates of α-amino acid derivatives with α-amino acid-based chiral Brønsted acids

K. Futatsugi, A. Yanagisawa and H. Yamamoto, Chem. Commun., 2003, 566
DOI: 10.1039/B211523A

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