Issue 18, 2002
From the journal:

Chemical Communications

Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics†

Thorfinnur Gunnlaugsson,*a   R. Jeremy H. Davies,b   Mark Nieuwenhuyzen,c   Clarke S. Stevenson,b   Romain Viguiera  and  Sinead Mulreadya  

* Corresponding authors

a Department of Chemistry, Trinity College Dublin, Dublin 2, Ireland
E-mail: gunnlaut@tcd.ie
Fax: 00 353 1 671 2826
Tel: 00 353 1 608 3459

b School of Biology and Biochemistry, Queen’s University of Belfast, Belfast, Northern Ireland, UK

c School of Chemistry, Queen’s University of Belfast, Belfast, Northern Ireland, UK

Abstract

The lanthanide ion based macrocyclic complexes 1·Ln mimic the hydrophobic nature of ribonucleases, where the lanthanide ions induce the formation of a hydrophobic cavity for 1, giving rise to a large order of magnitude enhancement in the hydrolytic cleavage of HPNP.

Graphical abstract: Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics

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Article information

DOI
https://doi.org/10.1039/B205349G
Article type
Communication
Submitted
06 Jun 2002
Accepted
05 Aug 2002
First published
22 Aug 2002

Chem. Commun., 2002, 2136-2137

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Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics

T. Gunnlaugsson, R. J. H. Davies, M. Nieuwenhuyzen, C. S. Stevenson, R. Viguier and S. Mulready, Chem. Commun., 2002, 2136 DOI: 10.1039/B205349G

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