Issue 18, 2001
From the journal:

Chemical Communications

Incorporation of a novel nucleobase allows stable oligonucleotide-directed triple helix formation at the target sequence containing a purine·pyrimidine interruption†

Dominique Guianvarc'h,a   Rachid Benhida,a   Jean-Louis Fourrey,*a   Rosalie Maurisseb  and  Jian-Sheng Sun*b  

* Corresponding authors

a Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, Gif-sur-Yvette Cédex, France
E-mail: fourrey@icsn.cnrs-gif.fr
Fax: +33-1-69077247
Tel: +33-0169283053

b Laboratoire de Biophysique, UMR 8646 CNRS-Muséum National d’Histoire Naturelle, INSERM U201, 43 rue Cuvier, Paris Cedex 05, France
E-mail: sun@mnhn.fr
Fax: +33-1-69077247
Tel: +33-01407937

Abstract

Thermal denaturation experiments have established that an oligonucleotide incorporating the artificial nucleobase S, does form a stable triplex with a double stranded DNA which exhibits a pyrimidine interruption within the oligopurine sequence.

Graphical abstract: Incorporation of a novel nucleobase allows stable oligonucleotide-directed triple helix formation at the target sequence containing a purine·pyrimidine interruption

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Article information

DOI
https://doi.org/10.1039/B103743A
Article type
Communication
Submitted
25 Apr 2001
Accepted
21 Jul 2001
First published
23 Aug 2001

Chem. Commun., 2001, 1814-1815

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Incorporation of a novel nucleobase allows stable oligonucleotide-directed triple helix formation at the target sequence containing a purine·pyrimidine interruption

D. Guianvarc'h, R. Benhida, J. Fourrey, R. Maurisse and J. Sun, Chem. Commun., 2001, 1814 DOI: 10.1039/B103743A

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