Issue 11, 2001
From the journal:

Chemical Communications

Conversion of the carboxy group of sialic acid donors to a protected hydroxymethyl group yields an efficient reagent for the synthesis of the unnatural beta-linkage

Xin-Shan Ye,a   Xuefei Huanga  and  Chi-Huey Wong*a  

* Corresponding authors

a Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA.
E-mail: wong@scripps.edu

Abstract

New sialyl donors with a protected hydroxymethyl group at the anomeric center are over 1000 times more reactive than the normal ester containing sialylation reagent and give excellent yield (>90%) with unusually high β-stereoselectivity in sialylation.

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Article information

DOI
https://doi.org/10.1039/B102166B
Article type
Communication
Submitted
05 Mar 2001
Accepted
04 Apr 2001
First published
10 May 2001

Chem. Commun., 2001, 974-975

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Conversion of the carboxy group of sialic acid donors to a protected hydroxymethyl group yields an efficient reagent for the synthesis of the unnatural beta-linkage

X. Ye, X. Huang and C. Wong, Chem. Commun., 2001, 974 DOI: 10.1039/B102166B

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