Issue 2, 2001

Epoxyalcohol route to hydroxyethylenedipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)

Abstract

A stereoselective synthesis of the diaminoalcohol core of Ritonavir illustrates a novel approach to hydroxyethylene dipeptide isosteres, based on the regioselective reduction of amino acid-derived epoxyalcohols.

Article information

Article type
Communication
Submitted
13 Jul 2000
Accepted
08 Dec 2000
First published
09 Jan 2001

Chem. Commun., 2001, 203-204

Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)

F. Benedetti and S. Norbedo, Chem. Commun., 2001, 203 DOI: 10.1039/B005804L

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