Issue 17, 2000
From the journal:

Chemical Communications

Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

Yasuo Takeuchi,*a   Kumiko Azuma,a   Kentaro Takakura,a   Hitoshi Abea  and  Takashi Harayamaa  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka 1-1-1, Okayama, Japan.
E-mail: take@pharm.okayama-u.ac.jp

Abstract

The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((±)-3) using baker’s yeast.

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Article information

DOI
https://doi.org/10.1039/B005028H
Article type
Communication
Submitted
22 Jun 2000
Accepted
21 Jul 2000
First published
11 Aug 2000

Chem. Commun., 2000, 1643-1644

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Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction

Y. Takeuchi, K. Azuma, K. Takakura, H. Abe and T. Harayama, Chem. Commun., 2000, 1643 DOI: 10.1039/B005028H

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