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Issue 5, 2000
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Hydrolysis of an N-methylcarbamate by a catalytic antibodyThe synthesis and characterization of 4, 5, 6 and 7, preparation of monoclonal antibodies and ST51 Fab, experimental details for kinetic studies and Lineweaver–Burk plots are provided as electronic supplementary information, see http://www.rsc.org/suppdata/cc/b0/b000468p/

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Abstract

The first example of antibody-catalyzed hydrolysis of an N-methylcarbamate, a highly challenging reaction for antibody catalysis, was achieved by raising a monoclonal antibody to a phosphoramidate transition state analogue.

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Supplementary files

Article information


Submitted
23 Dec 1999
Accepted
21 Jan 2000
First published
24 Feb 2000

Chem. Commun., 2000, 385-386
Article type
Communication

Hydrolysis of an N-methylcarbamate by a catalytic antibody

A. N. Dinaut, M. Chen, A. Marks, R. A. Batey and S. D. Taylor, Chem. Commun., 2000, 385
DOI: 10.1039/B000468P

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