Jump to main content
Jump to site search

Issue 7, 2000
Previous Article Next Article

Asymmetric synthesis of alkyl 5-oxotetrahydrofuran-2-carboxylates by enantioselective hydrogenation of dialkyl 2-oxoglutarates over cinchona modified Pt/Al2O3catalysts

Author affiliations

Abstract

The first direct asymmetric synthesis of chiral alkyl 5-oxo-tetrahydrofuran-2-carboxylates (up to 96% ee), which are important building blocks in the synthesis of natural products by heterogeneous cinchona-modified Pt-catalyzed hydrogenation of α-ketoglutaric acid esters and subsequent cyclization of hydroxy esters is described.

Back to tab navigation

Additions and corrections

Article information


Submitted
12 Jan 2000
Accepted
22 Feb 2000
First published
17 Mar 2000

Chem. Commun., 2000, 555-556
Article type
Communication

Asymmetric synthesis of alkyl 5-oxotetrahydrofuran-2-carboxylates by enantioselective hydrogenation of dialkyl 2-oxoglutarates over cinchona modified Pt/Al2O3 catalysts

K. Balázsik, K. Szöri, K. Felföldi, B. Török and M. Bartók, Chem. Commun., 2000, 555
DOI: 10.1039/B000390P

Social activity

Search articles by author

Spotlight

Advertisements