Resolution of racemic Sb-chiral stibindoles using an optically active ortho-palladated benzylamine derivative, via their diastereomeric complexes

Abstract

Resolution of racemic Sb-chiral (±)-1-phenyl-2-trimethylsilylstibindole 1 has been achieved by the separation of a mixture of the diastereomeric palladium(II) complexes 3A and 3B derived from the reaction of (±)-1 with di-μ-chlorobis{(S)-2-[1-(dimethylamino)ethyl]phenyl-C ,N}dipalladium(II) 2, and optically pure 1-phenylstibindoles (-)-4 and (+)-4 have also been obtained from resolved (−)-1 and (+)-1, respectively.