SCHEDULED MAINTENANCE
4-(β-D-Galactopyranosyl)benzyl N,N,N′,N′-tetrakis(2-chloroethyl)phosphorodiamidate 1 was facilely biotransformed to the alkylating antitumor agent, N,N,N′,N′-tetrakis(2-chloroethyl) phosphorodiamidic acid, 4, when incubated with E. coli β-galactosidase, and therefore has potential for use in conjunction with gene-directed enzyme prodrug therapy.
A. K. Ghosh, S. Khan and D. Farquhar, Chem. Commun., 1999, 2527 DOI: 10.1039/A907719G
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