The tetrahydrofuranyl radical, generated from THF with Et3B in the presence of air, was found to react with aldehydes threo-selectively to afford α-substituted tetrahydrofuran-2-methanols, the common structural motifs of biologically active acetogenin polyketides, in moderate yields.
T. Yoshimitsu, M. Tsunoda and H. Nagaoka, Chem. Commun., 1999, 1745 DOI: 10.1039/A904745J
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