Highly selective chiral recognition on polymer supports: preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

Abstract

A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.