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Issue 24, 1996
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A synthetic route to the alkaloids of the ervatamine group. First total synthesis of (±)-6-oxo-16-episilicine

Abstract

A general route to silicine-methuenine alkaloids, exemplified by the synthesis of 6-oxo-16-episilicine, involving the nucleophilic addition of an acetylindole enolate to the pyridinium salt 2, methoxycarbonylation of the resulting 1,4-dihydropyridine, controlled catalytic hydrogenation, cyclization on the indole 3-position and further functional group manipulations, is reported.

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Article information


Chem. Commun., 1996, 2755-2756
Article type
Paper

A synthetic route to the alkaloids of the ervatamine group. First total synthesis of (±)-6-oxo-16-episilicine

M.-Lluïsa Bennasar, B. Vidal and J. Bosch, Chem. Commun., 1996, 2755
DOI: 10.1039/CC9960002755

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