A facile and efficient route to 3′,5′-diamino-3′,5′-dideoxynucleosides
Abstract
An efficient synthesis of 9-(3′,5′-diamino-3′-5′-dideoxy-β;-D-ribofuranosyl)adenine is described (40% overall yield); the synthetic route is applicable to all the nucleoside bases and can serve as a general procedure for the synthesis of 3′, 5′-diaminonucleosides.