A facile route to (+)- and (–)-trans-tetrahydro-5-oxo-2-pentylfuran-3-carboxylic acid, precursors of (+)- and (–)-methylenolactocin
Abstract
The enantioselective synthesis of the title γ-lactone intermediates is easily achieved by employing Porcine pancreas lipase catalysed hydrolysis of the corresponding esters as the key step.