Enantioselective addition of diethylzinc to aldehydes catalysed by a β-amino disulfide derived from L-proline
Abstract
A novel β-amino disulfide 2 is prepared and is effective at catalytic levels (1.25–2.5 mol%) in the enantioselective addition of diethylzinc to aldehydes providing (R)-secondary alcohols in up to 99% ee.