Issue 15, 1995

Application of enzymic Baeyer–Villiger oxidations of 2-substituted cycloalkanones to the total synthesis of (R)-(+)-lipoic acid

Abstract

Oxidation of ketones 1ah using a monooxygenase from Pseudomonas putida NCIMB 10007 gave the lactones 2ah in optically active form: lactone 2h was converted into (R)-(+)-lipoic acid 9.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 1563-1564

Application of enzymic Baeyer–Villiger oxidations of 2-substituted cycloalkanones to the total synthesis of (R)-(+)-lipoic acid

B. Adger, M. T. Bes, G. Grogan, R. McCague, S. Pedragosa-Moreau, S. M. Roberts, R. Villa, P. W. H. Wan and A. J. Willetts, J. Chem. Soc., Chem. Commun., 1995, 1563 DOI: 10.1039/C39950001563

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