Synthesis of all possible regioisomers of myo-inositol tetrakisphosphates
Abstract
Synthesis of all possible nine regioisomers of IP4, some of which are implicated as second messengers in the cellular signalling, was accomplished from myo-inositol via its dibenzoate derivatives (IBz2) as the key intermediates; base-catalysed isomerization of readily available I(1,4) Bz2 and its derivatives, followed by suitable separation procedures efficiently provided all nine regioisomers of IBz2.