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Issue 19, 1993
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Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates

Abstract

The designed hybrids 511 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 1218cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.

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Article information


J. Chem. Soc., Chem. Commun., 1993, 1525-1527
Article type
Paper

Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates

K. Toshima, K. Ohta, A. Ohashi, T. Nakamura, M. Nakata and S. Matsumura, J. Chem. Soc., Chem. Commun., 1993, 1525
DOI: 10.1039/C39930001525

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