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Issue 16, 1993
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Theoretical investigation of the origin of secondary α-deuterium kinetic isotope effects

Abstract

Although the secondary α-deuterium kinetic isotope effect upon the degenerate SN2 reaction of chloromethane with chloride anion arises from changes in α-CH stretching force constants, α-substitution by methyl and/or methoxy groups shows this inverse inductive contribution to be approximately constant and reveals that the trend in the isotope effect (calculated by semiempirical molecular orbital theory) is determined by changes in bending force constants, in accord with the conventional view.

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Article information


J. Chem. Soc., Chem. Commun., 1993, 1286-1287
Article type
Paper

Theoretical investigation of the origin of secondary α-deuterium kinetic isotope effects

J. A. Barnes and I. H. Williams, J. Chem. Soc., Chem. Commun., 1993, 1286
DOI: 10.1039/C39930001286

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