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Issue 2, 1993
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Identification of sugar degradation intermediates in a metalloporphyrin mediated DNA cleavage resulting from hydroxylation at C-5′

Abstract

Hydroxylation of poly(dA)·poly(dT) at the 5′ position of the deoxyribose units by the chemical nuclease Mn-TMPyP–KHSO5[Mn–TMPyP = manganese(III) complex of meso-tetrakis(4-N-methylpyridiniumyl)porphyrin] followed by an additional thermal step provides 5′-aldehyde-3′,4′-unsaturated nucleosides which can be reduced by sodium borohydride and then hydrogenated with palladium on charcoal giving 2′,3′-dideoxyribonucleosides having the natural β or the non-natural α configuration at 4′.

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Article information


J. Chem. Soc., Chem. Commun., 1993, 149-151
Article type
Paper

Identification of sugar degradation intermediates in a metalloporphyrin mediated DNA cleavage resulting from hydroxylation at C-5′

G. Pratviel, M. Pitié, C. Périgaud, G. Gosselin, J. Bernadou and B. Meunier, J. Chem. Soc., Chem. Commun., 1993, 149
DOI: 10.1039/C39930000149

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