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Issue 24, 1992
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A facile synthesis of 2-exo-methylenepenam; a potent intermediate for syntheses of new β-lactamase inhibitors

Abstract

A convenient synthesis of 2-exo-methylenepenams 1 is performed by reductive cyclization of allenecarboxylates 8 in a BiCl3/Zn bimetal redox system; subsequent manipulation of the 2-exo-methylene moiety of 1 opens new entries to β-lactam antibiotics and/or β-lactamase inhibitors.

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Article type: Paper
DOI: 10.1039/C39920001793
J. Chem. Soc., Chem. Commun., 1992, 1793-1794

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    A facile synthesis of 2-exo-methylenepenam; a potent intermediate for syntheses of new β-lactamase inhibitors

    H. Tanaka, Y. Kameyama, T. Yamauchi and S. Torii, J. Chem. Soc., Chem. Commun., 1992, 1793
    DOI: 10.1039/C39920001793

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