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Issue 19, 1992
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Studies of the interaction of a meta-hydroxy analogue of hoechst 33258 with DNA by melting temperature, footprinting and high-resolution 1H NMR spectroscopy

Abstract

A new analogue of Hoechst 33258 1 with a small structural change, i.e., the phenolic OH group being located meta rather than para, has been shown by footprinting, DNA melting studies and high-field 1H NMR spectroscopy to bind to the AATT sequences of DNA in a manner grossly similar to Hoechst 33258, although analysis by 1H NMR spectroscopy indicates that the phenolic end of the ligand could be prised away from the minor groove relative to Hoechst 33258, and that the major groove structure of d(CGCGAATTCGCG)2 is significantly perturbed by the binding of this Hoechst 33258 analogue.

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Article information


J. Chem. Soc., Chem. Commun., 1992, 1398-1399
Article type
Paper

Studies of the interaction of a meta-hydroxy analogue of hoechst 33258 with DNA by melting temperature, footprinting and high-resolution 1H NMR spectroscopy

S. E. S. Ebrahimi, J. A. Parkinson, K. R. Fox, J. H. McKie, J. Barber and K. T. Douglas, J. Chem. Soc., Chem. Commun., 1992, 1398
DOI: 10.1039/C39920001398

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