Synthesis and reactivity of a novel oxazolo[2, 3-c][1,4]benzodiazepine ring system with DNA recognition potential: a new class of anthramycins
Abstract
The new carbinolamine-containing oxazolo[2,3-c][1,4]benzodiazepine ring system has been synthesized, and its reactivity and stability have been compared with properties of the analogous pyrrolo[2,1-c][1,4]benzodiazepine system found in the DNA-binding anthramycin antitumour antibiotics.