Total synthesis of (5S)-thiolactomycin: revision of the absolute configuration of the natural product
Abstract
(5S)-Thiolactomycin (1) has been synthesized and found to be laevorotatory, [α]D20–172°(c 0.2, MeOH); the dextrorotatory natural product, [α]D20+176°(c 1.0, MeOH), is therefore the (5R)-enantiomer.