SCHEDULED MAINTENANCE
A flexible synthesis of D,L-γ-hydroxyphosphinothricin (GHPPT), a potent inhibitor of the enzyme glutamine synthetase, is described which features silicon-mediated addition of ethyl methylphosphinate to benzyl 2-benzyloxy-carbonylamino-4-oxobutyrate; selective deprotections yield the title compound and various derivatives.
D. M. Walker, J. F. McDonald and E. W. Logusch, J. Chem. Soc., Chem. Commun., 1987, 1710 DOI: 10.1039/C39870001710
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