Remarkable structural effects in the intramolecularly assisted hydrolysis of aryl chloroalkyl ketones
Abstract
The carbonyl-assisted intramolecular hydrolysis of 4-chloro-1-(4′-hydroxyphenyl)butan-1-one and related compounds is sensitive to the substitutional pattern on the phenyl ring as well as to the number of methylene groups between the carbonyl carbon and the carbon joined to the chlorine.