Wittig reactions with β-lactam carbonyls: a convenient means of protection. X-Ray crystal structure of p-nitrobenzyl-(2R,5R)-Z-7-methoxycarbonylmethylene-Z-3-(β-phthalimidoethylidene)-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
Abstract
Clavulanic acid derivatives and penicillin Vesters undergo Wittig reactions at the β-lactam carbonyl and the β-lactam can be regenerated by low-temperature ozonolysis; the crystal structure of one of the products is reported.