A new rearrangement of a 4-mercaptoazetidin-2-one via a thioaldehyde intermediate
Abstract
The 4-mercaptoazetidin-2-one (4) was prepared by a short and efficient route from phthalimidopenicillin methyl ester, and its pyrolysis provided a new γ-lactam (7a) stereospecifically via an ene reaction of a thioaldehyde.