2H n.m.r. determination of the stereochemistry of an allylic displacement in the biosynthesis of virescenol B
Abstract
Feeding of (5R)-[5-2H]mevalonate to Oospora virescens and 2H n.m.r. analysis of a derivative of the resulting virescenol B establish that the allylic displacement of pyrophosphate which generates ring c takes place with overall anti stereochemistry.