Synthesis via a bicyclic β-lactam of (αS,2R/αR,2S)-α-aminopiperidine-2-acetic acid, an amino-acid related to the anti-tumour agent ‘593A’[3,6-bis-(5-chloro-2-piperidyl)piperazine-2,5-dione]
Abstract
A stereoselective synthesis of (αS,2R/αR,2S)-α-aminopiperidine-2-acetic acid (2a) from ethyl 8-oxo-1-azabicyclo[4.2.0]octane-7-carboxylate (4a) is described.