6β-Bromopenicillanic acid (1) binds to serine-44 of the β-lactamase I from B. cereus as a dihydrothiazine derivative, which undergoes further chemical changes during cleavage of the enzyme.
B. S. Orlek, P. G. Sammes, V. Knott-Hunziker and S. G. Waley, J. Chem. Soc., Chem. Commun., 1979, 962 DOI: 10.1039/C39790000962
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