2H nuclear magnetic resonance studies on biosynthesis: stereochemistry of the 5′-hydrogen atoms of griseofulvin derived from griseophenone B and 4-demethyldehydrogriseofulvin
Abstract
2 H N.m.r. spectroscopy has been used to establish that in Penicillium urticae, griseofulvin is biosynthesized with the 5′α-configuration of deuterium from [5′-2H]griseophenone B and 4-demethyl-[5′-2H]-dehydrogriseofulvin.