Issue 5, 1969

Fatty acid cyclization in the biosynthesis of brefeldin-A: a new route to some fungal metabolites

Abstract

Specific incorporation of 14C from [9-14C]palmitate into the antibiotic brefeldin-A is observed, and explained in terms of biosynthesis via an oxygenative 5,9-cyclization of a 1,15-lactonized C16-polyene acid.

Article information

Article type
Paper

J. Chem. Soc. D, 1969, 237-238

Fatty acid cyclization in the biosynthesis of brefeldin-A: a new route to some fungal metabolites

J. D. Bu'Lock and P. T. Clay, J. Chem. Soc. D, 1969, 237 DOI: 10.1039/C29690000237

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