Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 10, 2020

Influence of the mechanical properties of biomaterials on degradability, cell behaviors and signaling pathways: current progress and challenges

Author affiliations

Abstract

The development of suitable biomaterials with the ability to improve repair and regeneration of human tissues is continuously in progress, and mechanical properties of biomaterials play a critical role in their success in the clinical setting. Both biomaterial degradability and signaling cascades of cell interactions with biomaterials are significantly influenced by the mechanical properties of biomaterials, determining the final repair effect of bio-implants. Actually, the mechanical properties of biomaterials play a critical role in designing and developing medical material products both in research and in practice. Currently, advances in mechanics have provided new possibilities for researchers to investigate and modulate both the substrates and cell behaviors with respect to material perfection in tissue engineering. Achieving convenient and accurate approaches for producing different types of biomaterials is now possible by applying computerized methods. In this review, we have systematically clarified the influence of several selected mechanical properties of biomaterials (including stress/strain, elasticity/stiffness and certain time-dependent mechanical properties) on biomaterial degradability, cell behaviors and signaling pathways. Furthermore, the mechanical design targets and approaches for optimizing the mechanical properties of biomaterials, as well as the challenges and prospects are elaborated. This review will certainly bring up new ideas and possibilities for the field of tissue engineering and regenerative biomaterials.

Graphical abstract: Influence of the mechanical properties of biomaterials on degradability, cell behaviors and signaling pathways: current progress and challenges

Article information


Submitted
18 Feb 2020
Accepted
03 Apr 2020
First published
06 Apr 2020

Biomater. Sci., 2020,8, 2714-2733
Article type
Review Article

Influence of the mechanical properties of biomaterials on degradability, cell behaviors and signaling pathways: current progress and challenges

L. Wang, C. Wang, S. Wu, Y. Fan and X. Li, Biomater. Sci., 2020, 8, 2714 DOI: 10.1039/D0BM00269K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements