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Issue 10, 2020

Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

Author affiliations

Abstract

Nanoparticles have been widely used for many applications such as catalysis, biomedicine, or self-healing. Core–shell nanoparticles are very promising for biomedical applications due to several features such as possibility of sequence-controlled release of drugs and protection of sensitive payloads from surrounding environment. Core–shell structures incorporating payloads such as drugs, peptides, or hormones have been investigated in pre-clinical studies. The present review describes state of the art techniques for designing core–shell particles for biomedical applications. We also present recent advances in the field of drug, protein/peptide, and gene delivery using different types of core–shell nanoparticles. The function of core–shell particles as contrast agents and labels for bioimaging in magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography imaging (CT), ultrasound, and optical imaging is highlighted as well as their applications as biosensors.

Graphical abstract: Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

Article information


Submitted
21 Nov 2019
Accepted
14 Apr 2020
First published
22 Apr 2020

Biomater. Sci., 2020,8, 2756-2770
Article type
Review Article

Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

R. Jenjob, T. Phakkeeree and D. Crespy, Biomater. Sci., 2020, 8, 2756 DOI: 10.1039/C9BM01872G

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