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Issue 1, 2020
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Robust alginate/hyaluronic acid thiol–yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

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Abstract

Hydrogels based on hyaluronic acid (HA) exhibit great potential as tissue engineering (TE) scaffolds as a consequence of their unique biological features. Herein, we examine how the advantages of two natural polymers (i.e. HA and alginate) are combined with the efficiency and rapid nature of the thiol–yne click chemistry reaction to obtain biocompatible matrices with tailored properties. Our injectable click-hydrogels revealed excellent mechanical performance, long-term stability, high cytocompatibility and adequate stiffness for the targeted application. This simple approach yielded HA hydrogels with characteristics that make them suitable for applications as 3D scaffolds to support and promote soft tissue regeneration.

Graphical abstract: Robust alginate/hyaluronic acid thiol–yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

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Supplementary files

Article information


Submitted
16 Sep 2019
Accepted
31 Oct 2019
First published
06 Nov 2019

This article is Open Access

Biomater. Sci., 2020,8, 405-412
Article type
Paper

Robust alginate/hyaluronic acid thiol–yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

M. M. Pérez-Madrigal, J. E. Shaw, M. C. Arno, J. A. Hoyland, S. M. Richardson and A. P. Dove, Biomater. Sci., 2020, 8, 405
DOI: 10.1039/C9BM01494B

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