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Issue 9, 2019
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Adaptive control in lubrication, adhesion, and hemostasis by Chitosan–Catechol–pNIPAM

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Abstract

Bio-inspired wet adhesives attract considerable attention in the biomedical field. However, achieving reversible and controllable wet adhesion still remains a challenging issue. In this study, we report a new thermo-responsive polysaccharide wet adhesive conjugate named Chitosan–Catechol–poly(N-isopropyl acrylamide) (Chitosan–Catechol–pNIPAM), where catechol, the wet adhesive moiety, and pNIPAM, the thermal responsive group, are chemically tethered to a chitosan backbone. The as-synthesized Chitosan–Catechol–pNIPAM presents a reversible sol–gel transition behavior when the temperature is cycled below and above the lower critical solution temperature (LCST, 35 °C), along with dynamic switching between lubrication and wet adhesion on various materials. Based on these excellent features, Chitosan–Catechol–pNIPAM can realize controllable attachment/detachment behavior over the skin through heating/cooling processes. Due to its good biocompatibility, the Chitosan–Catechol–pNIPAM coated syringe needles exhibit instant hemostasis after removing the needles from the punctured sites of mouse veins. Overall, the as-synthesized Chitosan–Catechol–pNIPAM is expected to be used as a new intelligent adhesive in various biomedical settings.

Graphical abstract: Adaptive control in lubrication, adhesion, and hemostasis by Chitosan–Catechol–pNIPAM

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Publication details

The article was received on 02 May 2019, accepted on 01 Jul 2019 and first published on 04 Jul 2019


Article type: Communication
DOI: 10.1039/C9BM00697D
Biomater. Sci., 2019,7, 3599-3608

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    Adaptive control in lubrication, adhesion, and hemostasis by Chitosan–Catechol–pNIPAM

    R. Xu, S. Ma, Y. Wu, H. Lee, F. Zhou and W. Liu, Biomater. Sci., 2019, 7, 3599
    DOI: 10.1039/C9BM00697D

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