Issue 4, 2019
From the journal:

Biomaterials Science

Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery†

Shigeo Takeda,‡a   Tomoki Nishimura, ORCID logo ‡a   Kaori Umezaki,a   Akiko Kubo,b   Michiyo Yanase,b   Shin-ichi Sawada,a   Yoshihiro Sasakia  and  Kazunari Akiyoshi*a  

* Corresponding authors

a Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: akiyoshi@bio.polym.kyoto-u.ac.jp

b Institute of Health Sciences, Ezaki Glico Co., Ltd, 4-6-5, Utajima, Nishiyodogawa-ku, Osaka, Japan

Abstract

We report the combined enzymatic synthesis of five glucan dendrimers with control of molecular weight and particle size. Amphiphilic properties were introduced through dodecyl group substitution. A Tokyo-green fluorescence assay showed that amphiphilic glucan dendrimers were able to successfully deliver active β-galactosidase to cells.

Graphical abstract: Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8BM01627E
Article type
Paper
Submitted
14 Dec 2018
Accepted
15 Jan 2019
First published
30 Jan 2019

Biomater. Sci., 2019,7, 1617-1622

Permissions

Request permissions

Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

S. Takeda, T. Nishimura, K. Umezaki, A. Kubo, M. Yanase, S. Sawada, Y. Sasaki and K. Akiyoshi, Biomater. Sci., 2019, 7, 1617 DOI: 10.1039/C8BM01627E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements