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Issue 9, 2019
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Native cardiac environment and its impact on engineering cardiac tissue

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Abstract

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) generally have an immature fetal-like phenotype when directly compared to isolated CMs from human hearts, despite significant advance in differentiation of human pluripotent stem cells (hPSCs) to multiple cardiac lineages. Therefore, hPSC-CMs may not accurately mimic all facets of healthy and diseased human adult CMs. During embryonic development, the cardiac extracellular matrix (ECM) experiences a gradual assembly of matrix proteins that transits along the maturation of CMs. Mimicking these dynamic stages may contribute to hPSC-CMs maturation in vitro. Thus, in this review, we describe the progressive build-up of the cardiac ECM during embryonic development, the ECM of the adult human heart and the application of natural and synthetic biomaterials for cardiac tissue engineering with hPSC-CMs.

Graphical abstract: Native cardiac environment and its impact on engineering cardiac tissue

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Publication details

The article was received on 23 Oct 2018, accepted on 16 Apr 2019 and first published on 24 Jul 2019


Article type: Review Article
DOI: 10.1039/C8BM01348A
Biomater. Sci., 2019,7, 3566-3580
  • Open access: Creative Commons BY license
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    Native cardiac environment and its impact on engineering cardiac tissue

    V. Schwach and R. Passier, Biomater. Sci., 2019, 7, 3566
    DOI: 10.1039/C8BM01348A

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