Issue 5, 2018
From the journal:

Biomaterials Science

Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation†

K. Uto, ORCID logo *ab   T. Aoyagi,c   C. A. DeForest ORCID logo d  and  M. Ebara ORCID logo *e  

* Corresponding authors

a International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
E-mail: UTO.Koichiro@nims.go.jp

b PRIME, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan

c Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan

d Department of Chemical Engineering, University of Washington, 4000 15th Ave NE, Seattle, WA 98195, USA

e International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
E-mail: EBARA.Mitsuhiro@nims.go.jp

Abstract

Temperature-responsive cell culture substrates reported here can be dynamically programmed to induce bulk softening and surface roughness changes in the presence of living cells. Alterations in hepatocellular function following temporally controlled substrate softening depend on the extent of stiff mechanical priming prior to user-induced material transition.

Graphical abstract: Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation

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Article information

DOI
https://doi.org/10.1039/C8BM00047F
Article type
Communication
Submitted
13 Jan 2018
Accepted
06 Mar 2018
First published
09 Mar 2018

Biomater. Sci., 2018,6, 1002-1006

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Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation

K. Uto, T. Aoyagi, C. A. DeForest and M. Ebara, Biomater. Sci., 2018, 6, 1002 DOI: 10.1039/C8BM00047F

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