Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 9, 2017
Previous Article Next Article

ε-Polylysine-based thermo-responsive adsorbents for immunoglobulin adsorption–desorption under mild conditions

Author affiliations

Abstract

Thermo-responsive adsorbents for immunoglobulin G (IgG) employing ε-polylysine (EPL) as a polymer backbone were developed. The introduction of mercaptoethylpyridine (MEP) as an IgG-binding ligand and hydrophobization of side chains afforded thermo-responsive IgG adsorbents, whose thermo-responsive IgG desorption ratio was up to 88% (EPL/MEP derivative 3m). The changes in surface densities of active MEP groups, which are caused by thermal conformational changes of the adsorbents, play key roles for IgG desorption. Although a trade-off of IgG adsorption capacity and IgG desorption ratio was observed, the present study offers a novel molecular design for thermo-responsive adsorbents with high synthetic accessibility and potentially low toxicity.

Graphical abstract: ε-Polylysine-based thermo-responsive adsorbents for immunoglobulin adsorption–desorption under mild conditions

Back to tab navigation

Supplementary files

Article information


Submitted
29 Apr 2017
Accepted
06 Jun 2017
First published
08 Jun 2017

Biomater. Sci., 2017,5, 1751-1755
Article type
Communication

ε-Polylysine-based thermo-responsive adsorbents for immunoglobulin adsorption–desorption under mild conditions

M. Maruyama and K. Shibuya, Biomater. Sci., 2017, 5, 1751
DOI: 10.1039/C7BM00390K

Social activity

Search articles by author

Spotlight

Advertisements