Issue 4, 2017
From the journal:

Biomaterials Science

Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery†

Xiaoli Wang, ORCID logo ‡a   Dandan Miao,‡a   Xiaoyu Liang,a   Jiayi Liang,a   Chao Zhang,a   Jing Yang,a   Deling Kong, ORCID logo ab   Chun Wangc  and  Hongfan Sun ORCID logo *a  

* Corresponding authors

a Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
E-mail: sun-hf@139.com

b The Key Laboratory of Bioactive Materials of Ministry of Education, Institute of Molecular Biology, College of Life Science, Nankai University, Tianjin, China

c Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA

Abstract

A novel bone-targeted delivery systems based on nanocapsules was developed utilizing a Zeolitic Imidazolate Framework (ZIF-8) as a template and catechol-modified gelatin as wall material. A targeting ligand was facilely conjugated on the surface of nanocapsules. Simvastatin was encapsulated within the nanocapsules with a loading of 37.9%. Hydroxyapatite binding and in vivo biodistribution of the drug-loaded nanocapsules were investigated.

Graphical abstract: Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery

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Article information

DOI
https://doi.org/10.1039/C6BM00915H
Article type
Communication
Submitted
15 Dec 2016
Accepted
09 Feb 2017
First published
01 Mar 2017

Biomater. Sci., 2017,5, 658-662

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Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery

X. Wang, D. Miao, X. Liang, J. Liang, C. Zhang, J. Yang, D. Kong, C. Wang and H. Sun, Biomater. Sci., 2017, 5, 658 DOI: 10.1039/C6BM00915H

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