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Issue 4, 2016
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Shape matters when engineering mesoporous silica-based nanomedicines

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Mesoporous silica nanomaterials have been successfully employed in the development of novel carriers for drug delivery. Numerous studies have been reported on engineering mesoporous silica-based carriers for drug loading, release, cellular uptake, and biocompatibility. A number of design parameters that govern the in vitro and in vivo performance of the carriers, including particle diameter, surface chemistry, and pore size, have been tuned to optimize nanomedicine efficacy. However, particle shape, which may generate a high impact on nanomedicine performance, has still not been thoroughly investigated. This is probably due to the limited availability of strategies and techniques to produce non-spherical mesoporous silica nanomaterials. Recent breakthroughs in controlling the particle shape of mesoporous silica nanomaterials have confirmed the important roles of shape on nanomedicine development. This review article introduces various fabrication methods for non-spherical mesoporous silica nanomaterials, including rod, ellipsoid, film, platelet/sheet, and cube, and the roles of particle shape in nanomedicine applications.

Graphical abstract: Shape matters when engineering mesoporous silica-based nanomedicines

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Publication details

The article was received on 09 Dec 2015, accepted on 11 Jan 2016 and first published on 28 Jan 2016

Article type: Review Article
DOI: 10.1039/C5BM00589B
Biomater. Sci., 2016,4, 575-591

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    Shape matters when engineering mesoporous silica-based nanomedicines

    N. Hao, L. Li and F. Tang, Biomater. Sci., 2016, 4, 575
    DOI: 10.1039/C5BM00589B

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