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Issue 2, 2016
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Theranostics for hepatocellular carcinoma with Fe3O4@ZnO nanocomposites

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Abstract

The purpose of the current study is to investigate Fe3O4@ZnO nanocomposites as theranostic agents for hepatocellular carcinoma (HCC). Initially, the transferrin receptor antibody (TfR Ab) functionalized Fe3O4@ZnO nanocomposites, followed by loading with doxorubicin (Dox) and denoted as Fe3O4@ZnO/Dox/TfR Ab, were prepared as an all-in-one system allowing for a targeted drug delivery with simultaneous concurrent chemoradiotherapy and magnetic resonance imaging (MRI) monitoring. The diagnostic and therapeutic functionalities for HCC were evaluated in vitro and in a murine orthotopic models using cell viability assays, cell cycle tests, histopathological examinations, and serum biochemistry tests. The results demonstrated that Fe3O4@ZnO/Dox/TfR Ab could deliver Dox into the targeted HCC SMMC-7721 cells to enhance its chemotherapeutic efficiency. Besides, with the addition of short term and low dose X-ray illumination, the Fe3O4@ZnO nanocomposites showed excellent radiosensitizer properties, further attacking the cancer cells. Tumor cells were also mostly arrested at G2/M, resulting in a distinct inhibition of cell proliferation. In vivo, after the treatment, a noninvasive visualization monitoring through MRI showed that tumor growth was significantly suppressed by the targeted chemoradiotherapy mediated by Fe3O4@ZnO/Dox/TfR Ab. Therefore, Fe3O4@ZnO nanocomposites could mediate the theranostic strategy for hepatocellular carcinoma.

Graphical abstract: Theranostics for hepatocellular carcinoma with Fe3O4@ZnO nanocomposites

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Publication details

The article was received on 03 Sep 2015, accepted on 14 Oct 2015 and first published on 02 Nov 2015


Article type: Paper
DOI: 10.1039/C5BM00361J
Biomater. Sci., 2016,4, 288-298

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    Theranostics for hepatocellular carcinoma with Fe3O4@ZnO nanocomposites

    H. Zhang, N. Patel, S. Ding, J. Xiong and P. Wu, Biomater. Sci., 2016, 4, 288
    DOI: 10.1039/C5BM00361J

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