Jump to main content
Jump to site search

Issue 7, 2015
Previous Article Next Article

Redox-responsive self-assembled chain-shattering polymeric therapeutics

Author affiliations

Abstract

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via “Click” reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

Graphical abstract: Redox-responsive self-assembled chain-shattering polymeric therapeutics

Back to tab navigation

Supplementary files

Article information


Submitted
22 Dec 2014
Accepted
03 Feb 2015
First published
13 Feb 2015

Biomater. Sci., 2015,3, 1061-1065
Article type
Communication

Redox-responsive self-assembled chain-shattering polymeric therapeutics

K. Cai, J. Yen, Q. Yin, Y. Liu, Z. Song, S. Lezmi, Y. Zhang, X. Yang, W. G. Helferich and J. Cheng, Biomater. Sci., 2015, 3, 1061 DOI: 10.1039/C4BM00452C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements