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Issue 4, 2014
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“Nail” and “comb” effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

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Abstract

Thermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely “nail” for MCNOs and “comb” for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system.

Graphical abstract: “Nail” and “comb” effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

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Supplementary files

Article information


Submitted
22 Sep 2013
Accepted
14 Jan 2014
First published
07 Feb 2014

Biomater. Sci., 2014,2, 476-483
Article type
Paper

“Nail” and “comb” effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

W. Li, L. Deng, B. Moosa, G. Wang, A. Mashat and N. M. Khashab, Biomater. Sci., 2014, 2, 476
DOI: 10.1039/C3BM60222B

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