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Issue 2, 2014
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Delivery of doxorubicin in vitro and in vivo using bio-reductive cellulose nanogels

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Abstract

A methacrylation strategy was used to functionalize carboxymethyl cellulose and prepare redox-sensitive cellulose nanogels which contained disulfide bonds. Dynamic light scattering, zeta potential and electron microscopy were utilized to characterize these nanogels. It was found that these nanogels had a spherical morphology with a diameter of about 192 nm, and negative surface potential. These redox-sensitive nanogels were stable against high salt concentration but de-integrated in the reducing environment containing glutathione. When doxorubicin (DOX) was loaded into the nanogels, a high drug loading content (36%) and a high encapsulation efficiency (83%) were achieved. Confocal laser scanning microscopy and co-localization images showed that DOX-loaded nanogels were internalized by the cancer cells through endocytosis and the DOX could be delivered into the nucleus. Near-infrared fluorescence imaging biodistribution examination indicated that the nanogels could passively target to the tumor area by the EPR effect and had a significantly prolonged circulation time. In vivo antitumor evaluation found that DOX-loaded nanogels exhibited a significantly superior antitumor effect than the free DOX by combining the tumor volume measurement and the examination of cell apoptosis and proliferation in tumor tissues.

Graphical abstract: Delivery of doxorubicin in vitro and in vivo using bio-reductive cellulose nanogels

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Supplementary files

Article information


Submitted
18 Jul 2013
Accepted
09 Sep 2013
First published
07 Oct 2013

Biomater. Sci., 2014,2, 220-232
Article type
Paper

Delivery of doxorubicin in vitro and in vivo using bio-reductive cellulose nanogels

H. Qian, X. Wang, K. Yuan, C. Xie, W. Wu, X. Jiang and L. Hu, Biomater. Sci., 2014, 2, 220
DOI: 10.1039/C3BM60176E

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